I clean my house and my office before I leave. Last year, we traveled later in December than we usually do, and I told my son and his family that we would celebrate Christmas at their house so that I didn't have to get my holiday decorating done before I left (the year before I ended up doing all of my decorating Thanksgiving weekend). I cleaned everything, changed my sheets, towels, made sure that the cat food was available so that DS or DDIL could feed the cats, put my plants in the kitchen sink so all they had to do was spray them, and off we went. I returned to a house fully decorated for Christmas, and all the fixin's for Christmas dinner waiting for me. DS, DDIL and DGD all SWORE that Santa came while we were away. Of course, I ended up with the holiday mess anyway, but it wasn't too bad because I already had my spring reservations for WDW, and knew that I would be cleaning the house again before that trip!
Beth