CDC Notifies States, Large Cities To Prepare For Vaccine Distribution As Soon As Late October

[Pyotr]

Hey fam.

He‘s back!

Any news if you’re going to get the real vaccine any time soon?

The CDC put me next on the list as I’m considered a “Frontline Essential Worker,” so I’m pretty excited.

 

[Jonfw2]

He‘s back!

Any news if you’re going to get the real vaccine any time soon?

The CDC put me next on the list as I’m considered a “Frontline Essential Worker,” so I’m pretty excited.

congrats!!!

I received a note from our testing center last Friday saying they were told Moderna will soon be sending out instructions on getting the placebo group vaccinated. I’ve heard 1-2 weeks, but nothing official yet.

 

[dvcgirl67]

Hey fam.

Welcome back

 

[anniemae]

Dr. Fauci received the moderna vaccine today. Hopefully it will encourage others to do so who are on the fence!

 

[Jonfw2]

Study update: Moderna did a conference call today with their study locations. The purpose of the call (no specifics yet) was to finalize the approach going forward with the placebo group.

Pfizer elected to only allow people to be unblinded as their EUA group came up. For instance, when phase "1B" starts, they will allow all their study participants in that group to get their real vaccine if they got the placebo. Really, nobody will move up in line with this approach- they'll just make sure that placebo people won't have to wait any longer than needed.

Moderna is taking a very different approach: they WILL vaccinate the entire placebo group upfront regardless of their EUA group. They will do so under one of two different approaches which is being decide on now: they will either do a "crossover" unblinding in which EVERYONE in the study will get two more shots, the opposite of what they got the first time. The other, much easier, approach is to simply bring back all the placebo people ASAP for the real thing.

So why is Moderna's response so different? Two reasons: one, it turns out 25% of the participants in their study work in health care, and they are already starting to see volunteers leave- unblinding would allow at least a little bit of ongoing control. And two, it turns out from day one, Moderna reserved doses of the real vaccine for the placebo group. Apparently, these cannot be used under the EUA because they're designated for "research" and they will either have to be used for the study or they will just expire unused.

I should have more information very soon.

 

[Jonfw2]

New deal between the US govt and Pfizer- 70 to 100 million more doses by second quarter.

 

[anniemae]

I just hope the J & J vaccine will be as good as the two we currently have. I think they will be done with phase 3 by end of January. So far it looks promising. Fingers crossed.

 

[bcla]

I just hope the J & J vaccine will be as good as the two we currently have. I think they will be done with phase 3 by end of January. So far it looks promising. Fingers crossed.

How many different vaccines are showing promise besides Pfizer/BioNTech and Moderna? I thought that the Astra Zeneca/Oxford vaccine was showing some promise.

Eventually this might be like vaccines with multiple versions that are all considered acceptable. When I got my dog vaccinated for rabies, the animal license form has boxes for at least a half dozen different approved rabies vaccines. It was a requirement that the particular vaccine be identified.

 

[Jonfw2]

How many different vaccines are showing promise besides Pfizer/BioNTech and Moderna? I thought that the Astra Zeneca/Oxford vaccine was showing some promise.

Eventually this might be like vaccines with multiple versions that are all considered acceptable. When I got my dog vaccinated for rabies, the animal license form has boxes for at least a half dozen different approved rabies vaccines. It was a requirement that the particular vaccine be identified.

AZ is really in a holding pattern in the US. I think Novavax will be next. And then maybe Merck?

 

[anniemae]

How many different vaccines are showing promise besides Pfizer/BioNTech and Moderna? I thought that the Astra Zeneca/Oxford vaccine was showing some promise.

Eventually this might be like vaccines with multiple versions that are all considered acceptable. When I got my dog vaccinated for rabies, the animal license form has boxes for at least a half dozen different approved rabies vaccines. It was a requirement that the particular vaccine be identified.

I was wondering what happens with the second dose. If you get Pfizer, you have to get the same brand for your second dose, but what if the place you go has another brand in stock when it's time for the booster? I thought J & J were next up, but maybe not. They are supposed to be good because it is one dose, it's cheap to make, does not require the deep freeze storage, and it's very effective.

 

[bcla]

I was wondering what happens with the second dose. If you get Pfizer, you have to get the same brand for your second dose, but what if the place you go has another brand in stock when it's time for the booster? I thought J & J were next up, but maybe not. They are supposed to be good because it is one dose, it's cheap to make, does not require the deep freeze storage, and it's very effective.

I was thinking about that too. There might be the possibility that the antibodies produced are slightly different. Heck - in the future it might get to the point where there's enough production that everyone who can will get a combination of these if each one might afford slightly different protection - kind of like how "drug cocktails" have proven to be more effective than single drugs.

 

[Jonfw2]

I was wondering what happens with the second dose. If you get Pfizer, you have to get the same brand for your second dose, but what if the place you go has another brand in stock when it's time for the booster? I thought J & J were next up, but maybe not. They are supposed to be good because it is one dose, it's cheap to make, does not require the deep freeze storage, and it's very effective.

JnJ definitely next if they get EUA.

 

[Jonfw2]

With the new Pfizer deal, the US has secured 1 billion doses of vaccines (some of which have not yet received EUA).

 

[dvcgirl67]

With the new Pfizer deal, the US has secured 1 billion doses of vaccines (some of which have not yet received EUA).

When will the new Pfizer doses be coming? 2nd quarter?

I know there will be bumps in the road, but I for one am looking forward to whenever they get these vaccines out to the general community. Only 556K people were vaccinated in the first week. I think the estimate was that there was going to be 45 million doses available to vaccinate 22.5 million people by the end of this year. I'm not sure how we reach that milestone at the current pace.

 

[Jonfw2]

When will the new Pfizer doses be coming? 2nd quarter?

I know there will be bumps in the road, but I for one am looking forward to whenever they get these vaccines out to the general community. Only 556K people were vaccinated in the first week. I think the estimate was that there was going to be 45 million doses available to vaccinate 22.5 million people by the end of this year. I'm not sure how we reach that milestone at the current pace.

HUGE caveat on that number- more than half the states just haven’t reported any numbers yet. It’s likely far higher.

 

[dvcgirl67]

HUGE caveat on that number- more than half the states just haven’t reported any numbers yet. It’s likely far higher.

Ok, didn't see that. That's the number from the C.D.C.

 

[Jonfw2]

Ok, didn't see that. That's the number from the C.D.C.

Here's a great link from the NYT...that number is also probably 3 days old, as this one is two days old. They do update it though if you refresh every day or so.

https://www.nytimes.com/interactive/2020/us/covid-19-vaccine-doses.html

 

[dvcgirl67]

Here's a great link from the NYT...that number is also probably 3 days old, as this one is two days old. They do update it though if you refresh every day or so.

https://www.nytimes.com/interactive/2020/us/covid-19-vaccine-doses.html

Thanks...I'll check it out. I wish we could see up to the minute kind of "daily" reports of actual vaccinations, like we do for cases, hospitalizations and deaths. Or that Johns Hopkins, The Covid Tracking Project...etc, would add that new category to their covid sites. The citizens of this nation sure could use some good news.

 

[mom2rtk]

When will the new Pfizer doses be coming? 2nd quarter?

I know there will be bumps in the road, but I for one am looking forward to whenever they get these vaccines out to the general community. Only 556K people were vaccinated in the first week. I think the estimate was that there was going to be 45 million doses available to vaccinate 22.5 million people by the end of this year. I'm not sure how we reach that milestone at the current pace.

I'm sure they don't expect to keep that pace for long. They're just ramping up.

 

[Jonfw2]

Thanks...I'll check it out. I wish we could see up to the minute kind of "daily" reports of actual vaccinations, like we do for cases, hospitalizations and deaths. Or that Johns Hopkins, The Covid Tracking Project...etc, would add that new category to their covid sites. The citizens of this nation sure could use some good news.

Agreed! I expect that will come, but I've been searching like crazy and there are several out there but they're all several days old and missing around half the data.