One question first. Will you have a car?
If so, then the location of your room won't be a factor and I'd probably go with something near WDW. We've had good luck with the hotels in "Marriott Village". They have a Courtyard, Fairfield Inn and Springhill Suits in one location. Often you can find good prices on one of them.
If you do not have a car and were hoping to use DME, then check around the airport for a hotel (again we prefer Marriott). Most of them offer free airport shuttles so you can get there, and then back to the airport in the morning to catch DME.