In order to deposit a check for our bank you sign the back of it and theoretically it's supposed to match that with your other signatures you've used. My husband had to do that just today after getting a reimbursement check in the mail from his HSA account after buying his eyeglasses online, yes he was able to mobile deposit it but he still needed to sign the back of it. That's what you're supposed to do that is. Back when health care companies were required to cover the costs of covid tests that was also something we had to do was sign the back of the reimbursement checks.
All the back of my cards (CC, checking, etc) say a signature is needed. Now whether everyone is doing that or not IDK. Your passport needs your signature on it so that's an occurrence there although no not a situation one would frequently encounter. DMV requires a signature for your DL and how often depends on a variety of things like the renewal cycle, the rules surrounding age, name changes, etc (although I know states have online renewals generally the DMV needs your signature at least initially at least ours does).
When we first did our mortgage in 2014 I do remember e-signing documents related to our buyer's agent but the actual closing docs were in person. Even our refi in 2020 was in person. I'm not sure if the companies have changed since then.
Bill pay (where you have your bank send a check on your behalf) has been around for ages, still that doesn't absolve from every situation in which case you may be needed to physically sign.