as an adult. How do you do this. I'm in my early 40's and have been very busy with life,kids,school,work,etc... Now things are easing up and I realize i have let go of all of my friendships. I have some friends at church and one good friend but they are in different places in their lives right now and it won't work. I'd love to have a group of girlfriends and some couples friends for dh and I. I wonder if it's possible to make friends like this at this point in our lives or is this something you can only do in hs and college, early single years?

Have you met any of your neighbors? Those are some of my very best friends. We're like family. Our families are all in the "same boat" and we do a lot of things together. 
Don't worry about the quantity of friends right now--just think about what you'd like to get involved in and then hopefully a friendship or two (or more) will evolve.