I stayed at Paradise Pier, as well as the Embassy Suites down the road, and, while I always tend to err on the safe side, I felt completely comfortable just locking my laptop and accessories inside my suitcase. Then I know it's at least locked somewhere but it's not out in the open.
I know it is highly unlikely that a CM or any hotel staff member would take anything at all from a room; however, I worked in hotels for two years, and while cleaning rooms, housekeepers are often doing several rooms on a floor at the same time, and leave the doors propped up on all of them whlle they are just in one room. Techinically, it could be very easy for someone to sneak into any one of those open rooms and grab something while the housekeeper is down the hall.
I always lock everything in the safe or in a suitcase while traveling. Better safe than sorry.
Good Luck and Have Fun!