I am dealing with this situation right now with two of my family members in PA. It is very hard not to be able to help them.
My niece, has been hospitalized twice since right before Christmas, depression as well as addiction issues. She is now home, but still very much in a dark mood. She does not really share at all what she is feeling so it is very hard to understand what is going on with her, and she pretty much just cuts herself off.
The other is my sister (my niece's mother) whose second husband of 16 years out of the blue on New Year's Day told her he didn't want to live there anymore, and moved in with a woman with whom the both had been friends (her husband died about a year ago, and my BIL and this woman had been together prior to the respective marriages) so.... my sister is now feeling deeply betrayed, etc, and is in a dark place as well. We normally would speak several times a week, just to chat about whatever, and now after several attempts to call, and getting the feeling that she really didn't want to talk, I wait for her to call - infrequently, and then basically just sit and let her talk. She is seeing a therapist several times a week, and is on meds etc.
They both know that I am here for them, but my attempts to reach out to them have not been well received, so I wait for them to come to me! This is really hard for me to see in my sister, as she is usually the STRONG one...