I wore the patches for the first time during my adoption trip overseas 16 years ago. I didn’t know anything about the eye dilations, and after wearing them for 24 hours I couldn’t see hardly at all when I arrived at my destination. It took 3 days to get back to normal, but they did return to normal. What I learned since that trip was to put them on in the bathroom where you can dispose of them immediately and then wash your hands well so there is no residue on your fingers. Anytime I accidentally touched them, which wasn’t often given they were behind my ear, I would wash my hands immediately. The main thing is not to touch your eyes if you have anything on your hands. I have worn them multiple times since then and had no issues with my eyes. I even wore them on a Disney Alaskan Cruise and had no issues as long as I was careful. I do limit now how long I wear them, though.