We have stayed at the Bernic on 47th (just a couple of blocks from 5th avenue and grand central) and at the Hampton on 54th (when you look it up online it comes up as Hampton Inn Central Park South). The Hampton was just a couple of blocks south of Central Park and close to broadway and the theatre district. I would stay at both again. Decent size rooms, clean and good locations to get around midtown easily. We have also stayed at the Millennium Hilton UN. While this hotel is nicer and has much larger rooms than the other two, its not really near anything unless you happen to be doing business at the UN! A side perk is since it is across the street from the UN, you can't beat the security at the hotel. Have fun in NYC!