See I'm the complete opposite. A few hours waiting around the airport is NOTHING compared to being stuck in a car for two days.
I love my friends and family.....but no, just no. I try to keep car trips to half a day. There are one of two times when we do end up driving because it's easier or cheaper in that specific case but I do it under protest.
We do a number of car trips and sure it's nice to have all that room and flexibility, but I don't want to lose 4 days of my time to driving.
I will pay more to fly somewhere if at all possible. I don't have a fear of flying, I am plus size but I fit in the seats, once I'm on vacation I want to get there and start having fun. Flying has some not so great points but it is so small compared to the advantages.
I travel light. I splurge on favorite snacks/lunches and trashy magazines. I rent movies from Itunes. I never take a carry on that won't fit under the seat cause the bin hogs are just more than I want to deal with. I try not to check more than one bag, by planning multi task clothing and combining items that will do the same job, but will do two if I know the situation at the other end. (thank goodness I only took one bag to Chicago, the EL was built before ADA and I had to do stairs with my luggage

should have done more research there). I try to get in the early boarding groups so I can scope out a good seat, and if I'm traveling with family or friends I cough up the extra money to pick seats or get early entry. I always remember that flying is not something everybody does, it's an adventure, it's a miracle of physics, it's really darn fast....except for that whole arrive two hours early thing.
In the end it's all attitude. I think of all the great things about flying, and it's pretty easy to ignore or at least tolerate the not so great.