Not so much now. Previously, we requested non-smoking for medical reasons, but we don't have to worry about that now.
Now if we are by ourselves, we usually only request a location within a resort, and most of the time, that is done through booking categories. For example, on our upcoming OKW trip, we are in the "near Hospitality House" category.
If we have guests, they tend to be older relatives and that often leads us to request 1st floor at OKW...again, for medical reasons.