CDC Notifies States, Large Cities To Prepare For Vaccine Distribution As Soon As Late October

[Jonfw2]

I read this morning that the F.D.A expects to take three weeks to review the application from Pfizer, and will then hand it off to an outside panel of experts who reviews the application again. That panel has scheduled a meeting for December 10th. Based on those dates, and conversations that Pfizer is now having with states, officials are expecting to get the first shipment of vaccines around the third week of December. I just heard the head of the Dept. of Health for Illinois say they expect to get about 400K doses by the end of the year. NJ is slated to get 260K doses. Illinois is about 50% larger by population than NJ, so lines up perfectly with those numbers.

And as I've said earlier, the first group will be "protected" from the virus one week post second injection, so that's about one month later. If all goes well, it's a safe bet that all frontline healthcare workers, first responders and even nursing home patients can be possibly be vaccinated by the end of January, early February. Especially when the Moderna vaccine comes into play.

Make no mistake though, we are going to have an *awful* December and likely a pretty awful January as well. But I really am starting to believe that by the spring, things are going to vastly improve.

I absolutely agree with this timeline. We’re SO CLOSE now people need to be smart for just a little while longer.

 

[snappy]

A little personal responsibility on everyone’s part during the next couple months would go a long way.

 

[kanerf]

When you see the unmasked you should just point at them, don't say anything, just point. If others see that and follow, the idiot may eventually get shamed and mask up. My mask does not protect me, but yours does protect me from you.

 

[sam_gordon]

When you see the unmasked you should just point at them, don't say anything, just point. If others see that and follow, the idiot may eventually get shamed and mask up. My mask does not protect me, but yours does protect me from you.

BS. Your mask absolutely protects you (not 100%, but mine doesn't protect you 100% either).

 

[wenrob]

When you see the unmasked you should just point at them, don't say anything, just point. If others see that and follow, the idiot may eventually get shamed and mask up. My mask does not protect me, but yours does protect me from you.

I have never believed that a mask didn’t help protect me and they have now confirmed that it indeed does help protect the wearer. So if you wear yours and I wear mine we’re creating a nice little barrier. Not 100% of course but far better than random some wear them, some don’t.

As far as shaming, I won’t do that. First, it doesn’t work. It only serves to make people more combative and defiant. If I find myself in a situation where someone refuses I will remove myself from it and if you’re someone I know who won’t do it for whatever reason well, I’ll see you on the other side of all of this. Hopefully.

 

[Wakey]

Astrazenica/ Oxford vaccine will be approved by U.K. Regulators shortly (working in tandem with phase 3), and will add a lot to the US stock. It will also work very well in elderly patients, have a 90% efficacy it is expected (Coronavirus are easy to target it turns out) and costs under $10 per vaccination. US has a lot if this ordered.

 

[*DisneyDreamer]

So we’ve heard about Pfizer/Biontech and Moderna vaccines. Any word on what other ones might be close to more info? The more we can get the better. Isn’t there one that was only a one dose unlike the others being 2? Curious how that one will do.

 

[DLgal]

So we’ve heard about Pfizer/Biontech and Moderna vaccines. Any word on what other ones might be close to more info? The more we can get the better. Isn’t there one that was only a one dose unlike the others being 2? Curious how that one will do.

Yes, the Johnson and Johnson one is a one dose vaccine that does not require ultra cold storage. It is refrigerator stable for 2 years in regular refrigeration. They also have a HUGE manufacturing presence and will be able to get out a billion doses by year end 2021, they say.

That one will have final data sometime in January, according to the company. It is not an RNA vaccine, but rather one that uses an inactivated adenovirus that is incapable of initiating replication in our cells, but which has been modified to include the SARS-COV2 spike protein, so it works by teaching the immune system to recognize the spike protein and kill the virus.

This vaccine or another that is similar will likely be the vaccine that ends up being used worldwide as well as in rural areas of the US due to its single dose and easy transport/storage ability.

 

[Colleen27]

Astrazenica/ Oxford vaccine will be approved by U.K. Regulators shortly (working in tandem with phase 3), and will add a lot to the US stock. It will also work very well in elderly patients, have a 90% efficacy it is expected (Coronavirus are easy to target it turns out) and costs under $10 per vaccination. US has a lot if this ordered.

That is one of the more fascinating aspects of this. Initially the forecasts were so cautious and hedged in language emphasizing the fact that we've never developed a vaccine for a coronavirus, so our best hope was to throw everything at the wall and hope that one or two might "stick". Now it seems to becoming clear that only lack of need/motivation stood between science and coronavirus vaccination, and it is sounding more and more like at least 3 and probably 4 of the vaccines in development will ultimately be approved for use, which is a better outcome than anyone I've been following would have argued for even a couple of months ago.

 

[dvcgirl67]

That is one of the more fascinating aspects of this. Initially the forecasts were so cautious and hedged in language emphasizing the fact that we've never developed a vaccine for a coronavirus, so our best hope was to throw everything at the wall and hope that one or two might "stick". Now it seems to becoming clear that only lack of need/motivation stood between science and coronavirus vaccination, and it is sounding more and more like at least 3 and probably 4 of the vaccines in development will ultimately be approved for use, which is a better outcome than anyone I've been following would have argued for even a couple of months ago.

Agree. I was reading about how the mRNA vaccines targeted the spike protein. Also that they knew in theory this would work, but not until the trails, did they *know*. I would say that there's a third component to this whole scientific boon....like you said, need/motivation....and money. There's never been a lot of money in vaccines for Big Pharma, but there sure is now.

 

[Wakey]

That is one of the more fascinating aspects of this. Initially the forecasts were so cautious and hedged in language emphasizing the fact that we've never developed a vaccine for a coronavirus, so our best hope was to throw everything at the wall and hope that one or two might "stick". Now it seems to becoming clear that only lack of need/motivation stood between science and coronavirus vaccination, and it is sounding more and more like at least 3 and probably 4 of the vaccines in development will ultimately be approved for use, which is a better outcome than anyone I've been following would have argued for even a couple of months ago.

The so called experts only had to look at chickens- a highly successful Coronavirus vaccine was made 40 years ago.
The spike is a real easy target for the immune system and thus a vaccine it seems.
No one would have guessed 90+ efficacy though first go.

 

[bethbuchall]

As part of their EUA filing, Pfizer has requested that the FDA allow their study to be unblinded and allow the whole placebo group access to their vaccine.

https://www.statnews.com/2020/11/12...-vaccine-the-question-of-when-is-complicated/

We've been discussing this and wondering whether we'd be offered vaccine or just told that we are in the placebo group (assuming that we are indeed in the placebo group). The paperwork that we signed did not mention that we'd be offered vaccine only that we'd be told if we did not get the vaccine so that we could get it when available. Initially, we were reluctant to take any vaccine doses away from health care professionals, first responders, high-risk individuals, etc., but then we decided if it is part of the study, it might not be available to other groups anyway. I am not willing to forego the vaccine to remain in a placebo arm, so I would drop out of the study if a vaccine from a different manufacturer became available to me. If Pfizer does make the vaccine available to study participants, that would at least keep us in the study.

It's a tough call, and we don't even know if it's ours to make yet.

 

[mefordis]

I have never believed that a mask didn’t help protect me and they have now confirmed that it indeed does help protect the wearer. So if you wear yours and I wear mine we’re creating a nice little barrier. Not 100% of course but far better than random some wear them, some don’t.

As far as shaming, I won’t do that. First, it doesn’t work. It only serves to make people more combative and defiant. If I find myself in a situation where someone refuses I will remove myself from it and if you’re someone I know who won’t do it for whatever reason well, I’ll see you on the other side of all of this. Hopefully.

I agree, I would not get involved with someone not wearing a mask. I just saw a video where a masked woman in NYC wouldn't let two young people enter an elevator because they were maskless. They ended up beating her pretty badly, all caught on video. Not worth it. Just mind your own business. and get away from the unmasked person.

 

[mefordis]

Agree. I was reading about how the mRNA vaccines targeted the spike protein. Also that they knew in theory this would work, but not until the trails, did they *know*. I would say that there's a third component to this whole scientific boon....like you said, need/motivation....and money. There's never been a lot of money in vaccines for Big Pharma, but there sure is now.

Vaccines generate billions of dollars in revenue for drug companies. Costs paid by the federal government — which purchases half of all the vaccines for the nation's children — have risen 15-fold since 1986

Once they took away liability for vaccine manufacturers in 1986 vaccines became profitable. Before that they were getting sued quite a bit, in particular for the Dtap side effects. They came to congress and said it just isn't worth it to continue to make vaccines. The answer to this was the 1986 the National Vaccine Injury Compensation Program (VICP), used to provide financial compensation to individuals who file a petition and are found to have been injured. The program is funded by a tax placed on each vaccine. Therefore, vaccines are not a product for which the drug companies can be found liable, while the other drugs they produce can.

 

[Colleen27]

I agree, I would not get involved with someone not wearing a mask. I just saw a video where a masked woman in NYC wouldn't let two young people enter an elevator because they were maskless. They ended up beating her pretty badly, all caught on video. Not worth it. Just mind your own business. and get away from the unmasked person.

Yeah, I wouldn't say anything for this reason - retail workers are mostly advised not to attempt to enforce their employers' mask mandates because there have been so many violent incidences sparked by irate anti-maskers - but it does get frustrating when getting away from the unmasked people means it is near impossible to even pop into the local gas station for a soda or do the grocery shopping. When I went to do the Thanksgiving shopping, there was a family where both parents and FIVE kids were shopping together, all unmasked, and I swear they were in every aisle I tried to go down!

 

[Jonfw2]

https://investor.regeneron.com/news...ov2-first-antibody-cocktail-covid-19-receive/

 

[dvcgirl67]

Vaccines generate billions of dollars in revenue for drug companies. Costs paid by the federal government — which purchases half of all the vaccines for the nation's children — have risen 15-fold since 1986

Once they took away liability for vaccine manufacturers in 1986 vaccines became profitable. Before that they were getting sued quite a bit, in particular for the Dtap side effects. They came to congress and said it just isn't worth it to continue to make vaccines. The answer to this was the 1986 the National Vaccine Injury Compensation Program (VICP), used to provide financial compensation to individuals who file a petition and are found to have been injured. The program is funded by a tax placed on each vaccine. Therefore, vaccines are not a product for which the drug companies can be found liable, while the other drugs they produce can.

Good point. I wasn't clear in making my point....I meant to say that there hasn't been a lot of money, or incentive for the drug companies to create vaccines for newly emergent diseases. Some of these companies have gone down this road before....in attempting to create vaccines for diseases like SARS and Zika, for example. They've spent hundreds of millions of dollars only to see the disease disappear or retreat rapidly. I've seen estimates that the COVID vaccine market may be 3-4 times the size of the influenza vaccine market.

In the end, there are a few reasons that we will have more than a few vaccines to fight COVID-19. There is an unprecedented level of government funding for these vaccines. There has also been a raging on-going pandemic, and so plenty of subjects available for their studies. And finally, there is an enormous market for their product.

 

[Southernmiss]

There can be odd people in masks and out of masks.

I was grocery shopping Friday, in a mask, keeping my distance.

I passed the same guy in several aisles who was wearing his mask.

On one aisle there was an item I needed out of my reach. I at a distanced asked him 'Excuse me sir, could you reach that item for me.' He responded with a shake no of his head and held up 2 fingers in the shape of a cross and moved on.

Well, alrighty then. That was the most odd masked interaction that I had encountered.

 

[dclpluto]

I am literally counting the days until we can get a vaccine. My 14 year old severe asthmatic jokes she will fight someone for a vaccine. We want it in a big way in our house. so if any of yall are higher on the list than we are and don't want it, by all means, bump us up to your spot. All joking aside, This is a game changer. We need this badly. I sincerely hope folks end up getting it.

your daughter should be high on the list. Its a shame that murders, rapists and child molesters and a lot of other bad people are in category 3 if they are in prison, jail, detention centers. They are the low of the low but they get priority. As long as your daughter continues to the right thing. Than she will be ok. In reality as long as we have to wear masks doesn’t really matter when I get the vaccine. I do the right thing so I will be ok.

 

[BlueStarryHat]

I have yet to encounter a person who refused to wear a mask in a store, but plenty of people with their noses out. I avoid them because they might as well not be wearing the thing at all. I *did* ask someone in the grocery checkout line who was right up my back to please take a few steps back. They harumphed and gave me the stinkeye, but stepped back. That's the closest I've come to a confrontation.