I am not typically prone to motion sickness, and I have to say I felt some butterflies in my belly. The actual motion really is minimal, though, so the closing eyes might help ... but since the whole point is to see the film, it might defeat the purpose. If there's a really long wait, I'd probably skip it. If a short wait, I'd give it a try and try really hard not to close your eyes.
Have fun! It is pretty cool. My dd4 kept lifting up her legs when we "flew" down low.