I live in central NC and have all my life. I live in Burlington but would recommend the Mebane area as it is growing fast but still has a small town feel. Plenty of acreage in that area.
As for snakes, yeah we have em. Black, copperhead, green, garter, corn etc. Point is I live in a rural area but dont see them very often. I know when to be on my toes, instinct I guess. Leave them alone they will leave you alone.
As for yanks in this area, lots of em moving this way but most people have no problem with this. I understand not wanting to live in the fridgid air all the time. We have four seasons though spring and fall seem shorter than they used too be.
Good luck in your move.