We live 1300 miles away, and we love to drive. With two adults and 2 kids, we've done the trip three times in a Saturn VUE and twice in a Toyota Prius.

The Prius has gotten too small, and the VUE had gotten too uncomfortable for a long trip. So, we just traded in the VUE for a Chrysler Town & Country minivan with the stow & go seats and electric everything. The main reason for the trade was to have a comfortable ride to WDW and DLR in 2012. So, we bought a car for Disney!
We make the trip in 2 1/2 days, stopping for 2 nights each way. DH and I have never been drive-straight-through people, even before kids. We tried 2 days with 1 overnight stop our last trip at Christmas because we were pressed for time. We hated it. So, we're back to 2 1/2 days for this next trip. In the summer, I pack a lunch for the first day, and we picnic at a rest stop. We also like to hit a Chick-Fil-A, preferable with a play area, because we don't have those up North. We have a couple of different routes that we use, depending on whether we're going to the Atlantic side or the Gulf side before or after WDW.
We are also going to invest in a GPS before our next trip, mostly for the traffic updates. We hit traffic in Birmingham on the way down and Atlanta on the way back, and we want to try and mitigate that next time around.