It is a fairly easy drive as long as you don't hit any accidents along the way. You take I-4 west to Tampa then merge right onto I-75 north. Take that to the Bush Gardens exit. I want to say it is only 1 or 2 exits up. I believe it is the Fowler Ave exit 265. After exit, head west on Fowler. There will be signs for parking on your left if I remember correctly.
I-4 can be like a parking lot at times near the attractions.. as you can see when you are there. Depending on the time of day, rush hour traffic, it should take you just over an hour to get there, again, if you don't hit an accident.