we drive from Southwest side of Houston area all the time.. matter of fact, just got back a couple days ago

it was a blast!
I drive straight thru. we leave at 3:00pm the day before check in and pull into the WDW resort at 5:30am. This includes 5 stops for restroom, fuel and some chickfila (the one in Covington, LA at about 8pm)
I can tell you I-10 is real touchy on where you should and shouldn't exit. I would hate to try to figure out where to stay. Over many trips I've pulled into bad situations with drug deals and straight up gangster stuff going down. Luckily I was able to pump my gas and do my thing without them getting injured but it could of been bad lol..
So we get to Disney with the kids fully rested and the wifey and I wide awake because we drove all night and are now at DISNEY!! We check-in and miraculously we almost always get our room (we fax confirmation with requests and noting we will be arriving at 5am). We unload into the room and hit rope drop every time. We also schedule a midmorning ADR at Crystal Palace so we ride for a couple hours getting most of the rides out of the way then we eat and then head back to the resort for a nap, then go to downtown or just chill in the heated pool
To make the drive easier I make short goals..
out of TX by 5pm
out of LA by 9:30pm
out of MS in under an hour
try to do AL in 45 minutes
then the tough stretch is from Pensacola to Tallahassee and then from Tal to Lake City..
PAY ATTENTION!!!
by this time for us its about 2-3am.. we are up chatting about stuff to entertain each other and there has been times when I have flown right through Lake City passing the exit for 75. It was a costly one hour mistake too.. Apparently, Florida doesn't believe in U-turns or exits and they want everyone to just go to Jacksonville.
I finally gave up and u-turned after 30 minutes of wrong travel. I never saw the no traffic u-turn sign..
So once you get on 75, you make short goals of Gainsville, Ocala, then the turnpike.. you get through the turnpike and BOOM WDW!!!
so must stop.... Covington, LA exit is nice.
any Bu-cee's you see in TX.
thats about it. I guess if you are not wanting to get to Disney you could go off the beaten path and hit some cool spots like the battle ship in Mobile...
oh in Mobile you get to drive in a tunnel!!
One trip I wasted an hour in Mobile because I'm a food lover at heart and wanted to eat at the city's top burger joint.. We drove to 2-3 of them and wasn't impress at all with the whole situation so we bailed..