Assuming you will be trading into a 2BR or larger, my personal preferences would be (more or less, in order):
--- any of the Disneys
--- any of the Marriotts
--- Sheraton's Vistana Villages
--- Star Island or Fairfield Star Island
--- Sunterra Cypress Pointe Grandvillas (location)
--- Orange Lake Country Club
--- Wyndham Palms
I think all of these are pretty nice and would provide a comfortable, clean & very pleasant resort for a home base. Good pools, attractively maintained resorts.
If none of those are available, then I'd consider:
--- Sheraton Vistana Resort
--- Polynesian Isles
--- Ron Jon/Liki Tiki
--- Sunterra Cypress Pointe (phase I)
--- Parkway International
--- Amerisuites VC at Calypso Cay
Personally, I'd avoid most of the others unless I really needed a certain date and there was very little to choose from at the last minute. Also, if you will be seeking a 1BR, then make sure you will have a full kitchen, not a partial or mini-kitchen. Full kitchens usually assure you of getting the better half of a larger lock-off unit. Considering the ease and low price of renting a studio from an owner (lower than your maint fees at your home resort), I wouldn't bother trading into one in Orlando. And don't accept a studio at Orange Lake for any reason - they don't have exterior windows, only window overlooking an interior common area. HTH.