My DH and I love the comedy club, try to go whever we are at Downtown Disney. The 80's club is a lot of fun, my friends and I always have a good time there. I have been to BET and Mannequins and they are ok, not my favorite. The Beach Club is ok, they have live bands which are pretty good.
If you really want to go clubbing, try Citywalk or Church Street. Have fun!