I know the Pinnacle Ridge winery is near Kutztown, but you are not going to find any hotels there. I agree with the PP about looking towards Reading. I know there is a small motel off of 78 on the way to Kutztown that I pass when I take my son back to Kutztown Univ. Can't think of the name of it though. Bashore & Stoudt has great fruit wines.
The winetrail website lists the Sheraton in Reading, but there are other nice hotels in Reading. You might even be able to add in some shopping at the Reading Outlets http://www.vfoutletcenter.com/
http://www.berkscountywinetrail.com/transportation.htm
There is a map on the winetrail website that may help narrow down the search. It looks like one of the wineries is near Mertztown which would include the B&B's that loveysbydesign listed
Biddingfortravel.com lists a few hotels in the Reading area:
3 Star
Sheraton Reading
Wyndham Abraham Lincoln
2.5 Star
Inn at Reading
2 Star
Days Inn Reading Wyomissing (formerly Wellesley Inn and Suites) LINK TO HOTEL REVIEW
Holiday Inn Express & Suites
Comfort Inn Reading
You may want to consider Naming Your own Price on Priceline to get a good deal on a room in the Reading area. There is a posting on the biddingfortravel.com list that someone just got the Wyndham for $49 a night.
The Sheraton Reading is decent...if it's the one I'm thinking about, it's off of 222, but not IN Reading itself. You want to stay out of Center City Reading...it's not the safest area to be.
Wyomissing is pretty nice and suburban, so that might be a good choice.

