We stayed at the Ramada two years ago, which is roughly the same distance as HoJo from the pedestrian entrance to the esplanade. All you're doing is walking there, passing the park gates, and walking through DTD to the start. You'll get a sense of how long it takes when you go to the expo for packet pickup since that's at the Disneyland hotel, but for us I think it was maybe a 20-25 minute walk -- bearing in mind your casual walking pace may vary from normal time to
0-dark-thirty...
If you start walking at 4:15 you should be fine.