My personal all time favorite book is, "One Hundred Years of Solitude", by Gabriel Garcia Marquez. I read 20 years ago in college and became a Marquez fan. The book is currently the Oprah Book Club pick.
A good series is the "Stone Gap" series, (Big Stone Gap, Big Cherry Holler, and Milk Glass Moon) by Adriana Trigiani. They are a bit fluffly, but they suck you right in and they are "feel good" books.
The book which I am currently reading is, "The Crimson Petal and the White", by Michel Faber. It is about 900 pages, but well worth the read. The New York Times said, "A big, sexy bravura novel. Wildly entertaining."
deno