Hotel room clutter drives me crazy too. Left to his own devices my husband will live out a duffel bag while the pile around it grows bigger and bigger and it drives me nuts. I was really worried about this for our room at Pop a couple weeks ago so I went out of my way to organize our room. Our situation was a little different from yours as we were traveling with a two year old girl instead of teen boys but I had typed all this out for another post so I'm just going to paste it here. Some of these ideas wouldn't apply to older kids obviously. Oh and we were driving instead of flying so I had the luxury of bringing all this stuff in our car. I'm not sure what we would have done if I'd been limited on my luggage.
Anyway, on the side of the bathroom door facing the sink, I hung one of those shoe rack things for toiletries, sunscreen, meds, anything like that and it was a lifesaver. It kept all that junk easily accessible instead of in a bag but it was OFF the sink top. I got one of those things you hang from a closet rail to sort of make shelves and this gave us TONS of room for socks, underwear, t shirts and all of DD's clothes. There are only 3 small drawers in the dresser in the room so this totally saved us. I hung it all the way over on the end of the close by the safe. Next to that I had a pop up laundry hamper. Also AWESOME for keeping dirty clothes from being in a random pile somewhere. We used the rest of the closet for the few hanging things we had and there were plenty of hangers for us, although I had been prepared to ask for more if necessary. On the shelf above the hanging bar, we had a diaper box and three of those closet maid square bin things. In one of them, I had dishes (sippy cups, emergency nap pacis, cereal bowls, etc.). The second was kind of house keeping stuff (Lysol wipes, a Ziploc full of clothespins that came in handy, boxes of large and small ziplocs, grocery bags for poopy dipes, papertowels etc.) The third bin was for the stuff I needed to replenish our park backpack each day (gum, glow sticks, hand sanitizer, etc.). There was just enough room for those items and a few other small things to be stashed up there. On the counter next to the sink, I brought a small dollar store plastic tub with holes in the sides for dirty dishes and then I used that when I washed. I filled the sink with dish soapy water, washed, and moved everything to the tub, then emptied the sink and rinsed the dishes and tub. I had some cheapo dish towels that could hang on the edge of that tub when not in use. We also brought a small foldable stool so DD could wash her hands by herself. DH thought that was crazy but it was so worth it. Also a help was a small plug in night light for right by the sink for nighttime. In the two small cubbies in the "dresser" I used one for a diaper changing supply area (we are having some potty training issues so our doctor recommended we give her a break on the trip) and the other for swim stuff (towels, suits, floaties) after it had time to dry. One of the cubbies in one bedside table was filled with our snacks and breakfast stuff that didn't need the fridge and the other cubby was for the few toys and books that we brought along. I brought a power strip and plugged it in by the small table so our electronics tended to accumulate there but since it wasn't covered with too much other junk, this was okay. We rented a stroller from Kingdom Strollers (highly recommended!) and because of the king bed, there was plenty of room to park it in front of the window. Also, I brought a Minnie dress up magnet kit and DD could play with it on the back of the door while we were getting ready or otherwise busy. I'm not sure why but this really kept her entertained.
I had to be on the ball about everybody putting their stuff where they were supposed to but having a spot for it to actually go made our week at Pop SO much more enjoyable than it would have been in a chaotic mess! I was quite proud of it really! I regret not taking pictures.
Good luck!