It sure is worth it, we do most of our trips that way. We aren't very far south of Atlanta and do it a couple times a year. I-75 is not bad if you drive over night.
We usually head out around midnight and arrive early enough to check in, get a bite of breakfast and head to EMH at DHS on Saturday morning, then we head home on Sunday or Monday after lunch.
Suzanne
If you get APs and go several times, sure. But because single or two day tickets are so much more expensive, I wouldn't do it as my only trip- which is how I was interpreting OP.