Many of the differences are things that a lot of folks don't care about. It seems you would get the most benefit from staying at a deluxe if you plan on spending A LOT of time in your room or at your resort. We've stayed at deluxes and moderates, but we are usually "park people", so we don't spend a whole lot of time enjoying the surroundings of the resort. I figure if we just want to hang around the room and use the pool, we can find much better options at places other than WDW.
I never really understood the need for turn down service, (I guess others like their bedspread pulled down for them), so that is a non starter for me. LOL, my wife and I really can't tell the difference between a double and a queen. Once you have enough drawer space for a weeks vacation, an extra drawer or 2 does nothing for me. Concierge service, once again if you're at the resort all day and night this may be useful.
Interior hallways, IMO, are much noisier than outside access. At the Poly you can always hear kids running and ADULTS yelling in the halls.
I think the only advantage, (To most people), would be location, location, location. It IS nice to take the monorail to the MK rather than wait for a bus, or walk to Epcot or MGM rather than a bus.
I say if you're going to Disney to hang around the resort for your vacation, go to a deluxe, (lol, or go elsewhere). If you're going to Disney for the 4 Theme Parks, Pleasure Island, golf, etc...Moderates are great.