I can tell you that we have driven to Orlando from Raleigh, NC and I have a Honda Pilot. I think we get similar gas mileage. I have a 20 gallon tank that I fill before we leave. We need to fill on the trip, again just after we leave to come home, again on the trip, and within a day after getting back. So that is a total of 5 tanks at $3.69 a gallon (average) You are looking at $370 for gas just from NC to Orlando. If you need a hotel both ways that is at least another $250....I can't comment on tolls as we have never hit them when we drive. Food which would be (for 5 people fast food) 2 meals each day another $125. Not to mention wear and tear on your car. Have you looked into AMTRAK? We wanted to try it out this year and it is very reasonable. We can take AMTRAK from Raleigh, NC to Orlando for $280 round trip for the 4 of us.