Most of your drive through Ohio will have plenty of places to stop-for us, it only takes 2 hours to reach Marietta. West Virginia will take about 3 1/2 hours to drive through. We always make a stop in Marietta before entering W. VA, then we don't need to stop again until we get south of Charleston. Traffic and lane changes can be tricky in Charleston so watch for it. After leaving Charleston, I-77 becomes the W. VA. turnpike (toll is at $2/car so have $8 in ones ready). There are travel plazas located on this road that are really nice. We like the one in Bluefield (last one in state), plenty of parking, places for the kids to expend energy, gas fill-up and food. After crossing into VA there are some places, but it only takes an hour to drive through, so we rarely stop in VA. At this point, you are pretty high up in the mountains so the scenery is beautiful.
N. Carolina will have plenty of places to stop. We have always stayed north of Charlotte and haven't found anywhere to feel unsafe. Hotel prices will be higher in the Lake Norman area, so we stay a little further north. Traffic can be heavy in Charlotte, depending on what time you drive through it. It takes about 2 1/2 hours to go through NC.
As I stated before, we have not had good luck at finding decent stops in SC. One particular stop had my husband getting us back in the van after noticing the bullet holes in the back of some of the parked vehicles. After that, we no longer stop between Charlotte and Columbia. Once you pass Columbia, we have not had a problem. The closer you get to reaching I-95, the more options you have for stopping. It takes about 3 1/2 hours to get through SC.
Georgia is next and only takes about an hour to drive through. You will have plenty of places to stop in GA. Once you hit the FL line, you have about 3 hours to go. You will have lots of options for stops, Jacksonville and Orlando can have heavy traffic. Depending on what time of the day, there is a road you can take to bypass Orlando. It is a toll road so sometimes we take it and other times we don't.
I hope this helps...we have driven this route so many times, I could probably make the trip in my sleep.