What's the purpose of the tissue? Is it to get broader coverage or to soften the light?
My flash, a Canon 580EX, comes with a built in diffuser that you can put over the flash when you want broader coverage. It doesn't really soften the light. I think you would have to have something larger than the flash head for that.
Here is my reasonining. The coverage area is determined by the angle at which light leaves the flash. If you focus it by zooming the flash, you'll get a smaller coverage area, but you'll get more light in that area. If you diffuse (scatter) the light coming out of the flash, it will go off in all directions. That means that it will light a larger area but with the same amount of light as it had before. Because of that, the light will be less bright in any one place. There will also be some light lost to the diffuser.
As for softening the light, my understanding is that the softness of the light depends on a combination of the size and distance of the light source from the subject. The bigger or closer the light source, the softer the light. Conversely, the smaller or farther the light source, the harder the light. Putting tissue directly on the flash will not appreciably change either the size or distance of the light source, so it shouldn't appreciably change it's softness. If you made a shield that was significantly larger than the flash head, that would soften the light.
I suppose that if you were in a small enough room, you could argue that the diffuser softens the light by sending a lot of it towards the walls and ceilings and that the bounces from those surfaces act to soften the light. If that's your plan, you'd probably be better off just bouncing the light off the ceiling.