My doctor had me start taking Align last week. Too soon to see if it helps, but I'm hoping. In fact I'm off to see my doctor in a few minutes to get a note for work. I've only worked 20 hours in the last month due to my IBS "incidents" and no more sick time is left. They were going to lay me off, but said if I get a note from the doc they'd put me on short term disablity.