For a long time, I wouldn't do this. If it was our first day and the room wasn't ready yet, I'd lug the laptop and huge camera bag to the park with us, and rent one of the large lockers there. (We typically use DME, so luggage wasn't an issue for arrival.)
If it was the last day of our trip and we were going to hang out at the pool until our flight, I'd leave the luggage with bell services and lock the laptop/camera up in one of the large lockers at the pool.
LOL, I guess as my laptop and camera started getting a little older, I'm not quite as paranoid about them any more. For the past few trips, I've just left everything with bell services.
We've never had any problems. They'll even put a "FRAGILE" tag on the bag if you ask them.
I will so, though, that before any trip where my laptop is going to get carried along, I do a full backup of all my files at home. That way, if the laptop is lost I haven't lost anything other than the laptop itself. The most valuable thing on it at the end of the trip is all the photographs we've taken while on vacation. I've purchased an 8GB SD card, and now use that to make a full backup of all pictures before we check out. That's kept in a different carry-on bag.