Poohbear123
<font color=CCCC00>Will travel without lipstick<br
- Joined
- Jul 27, 2000
- Messages
- 16,433
Second Opinion and Acupuncture! 4 is way to young to put down, my PW was paralized, had back surgery, and Acupuncture all at 6, and lived to be 16.
A: Prudence- The combination of phenobarbital and potassium bromide is considered to be pretty effective by most of the neurologists I have corresponded with. It is important to adjust phenobarbital levels based on the blood levels of the medication rather than by the starting dosage guidelines. Some dogs need significantly higher dosages than the the recommended guidelines for starting therapy. It is also important to monitor both the peak and the trough dosages of phenobarbital (just after the pill and just before the next pill) in order to assess what is happening when the medication is not working well. If potassium bromide has already been started please remember to be patient about its effects. It produces an appearance of drunkenness that lasts a couple of weeks and it takes up to 25 days to achieve stable blood levels so you have to give it some time to work while putting up with its side effects. These usually go away once the dog adjusts. If phenobarbital and potassium bromide don't work well other choices include felbamate, clonazepam and clorazepate for seizure control (usually used in combination with phenobarbital or even with phenobarbital, potassium bromide and one of these choices). It is very difficult to figure out the prognosis in seizure disorders when the underlying cause can not be established. I wish I could help with that aspect of your question but it just doesn't seem possible to do so. The neurologists at Virginia Tech are very good, in my opinion. If there is a way to help I really think they will find it if you keep in contact with them and let them know how things are progressing -- which is also very important to do with your local vet, too! Seizures require a lot of teamwork and a good level of communication between the owner and the veterinarians treating the case when they are not easily controlled.
Mike Richards, DVM
A: It is disheartening when seizure medications don't work well. I can not tell from your letter if this has been done, but checking the blood level of the phenobarbital is often the most reliable way to determine if effective levels are being reached in the bloodstream. Some dogs do require more phenobarbital than the maximum recommended dosages in order to achieve sufficient blood levels. If the phenobarbital blood levels are not within the therapeutic range, increasing it is OK.
Seizures may not be controlled even if the phenobarbital level is in the range in which it normally would work. Potassium bromide (KBr) is the medication most commonly used to supplement the effect of phenobarbital in that case. When you first put your dog on the KBr you will see almost all the things that first happened with phenobarbital -- the "drunken" appearance, falling, running into things, etc. This can go on for about 3 weeks and then the dog adjusts to the dosage. It is an effective combination and once your dog adjusts it doesn't seem to depress overall personality traits much.
Mike Richards, DVM

Magickndm said:Is your vet Greyhound savvy? They really are a different breed and sometimes conventional meds react differently to their systems.
If you've never read there, please post your problem on www.greytalk.com
You'll be amazed at all the other greys there who also have epilepsy. I'm sure someone there can give great advice too.
Best of luck.
i did some research on mine on the computer before and found it was not curable and nothing could actully stop hers. I just pray you dont go through what i did. 
to your family and Kimya 
Jennasis said:HAd Kimya to the vet with Dh this morning. Not thrilled about a few things but we'll know more when the bloo results come back in a day or two. I made DH request a thyroid panel. Vet didn't think it was necessary as a thyroid dysfunction was "unlikely", but she did it anyway. Let's be aggressive in our search here lady! Let's rule it all out before we chalk it up to in inoperable brain tumor!
We bumped her phenobarbitol up to an additional 1/2 pill twice a day so now she gets 150mg twice a day. The Potassium stays the same at 5.2 ml. Fingers crossed!
PS...an MRI at the state university hospital (NC State) is $1100 according to the vet.

