I doubt it can be guaranteed, but it might be possible just by chance.
It will all depend on your dates of stay, and who already at the resort is checking out that same day and what kind of rooms are being left vacant.
Your best bet is if someone is checking out of a 2-B/R lock off and it is scheduled to be used next as a single 1-B/R plus a Studio. In that case you could ask for those two specific rooms.
Otherwise if it's already split by a 1-B/R and a Studio, it would have to work out that the two current parties occupying the two separate villas are both checking out on the same date, the date you are checking in.
All you can do is get their early at check-in and make your request known. MS will do what they can.
Keep in mind that the 1-B/R and the Studio will still be keyed separately if you do get the rooms, and room charges will remain separate. As far as
DVC is concerned they are two separate rooms and two separate reservations. You on the other hand convert it into a 2-B/R unit simply by the two of you unlocking the two respective doors between the two units.
Good Luck. As mentioned earlier, go for it, but don't count on it and consider yourself fortunate if it works out.