I'm guessing that you mean the Express Checkout statement. Since you will only get express checkout if you provided a credit card at check-in, any charges made will already have been made on your card and you will owe nothing and won't have to go to the desk before leaving. Any charges added after that statement was prepared will still be charged to your card also.
If you didn't provide a credit card at check-in, you will still have to settle your account in some fashion.
Enjoy!