Ohana is my hands-down favorite. I've always loved it. Also, Citricos is a wonderful restaurant with wonderful food and service. I'll definitely go back there again.
If you are looking for non-signature I would say Boma, Kouzinna, or Ohana. I've heard that Ohana is wonderful about accommodating those with special dietary needs.
For me my favorite is Narcoossee's. (surf & turf)
My biggest disappointment and over rated is Le'Cellier (good but far from great)
My most pleasant surprise was the Captains Grille. (enjoyed the steak more than Le'Cellier)
Narcoossee's at GF surf and turf and Artists Point at the WL--very nice menu, a little different which is always fun. i especially like the bison and mushroom soup.
CA Grill... we went there twice on our last trip! All three of us love it-- including my 4 y.o. DD! If you go, get the pork tenderloin with goat cheese polenta--- AMAZING!
DH and I just did the Sweetheart for 2 at Citricos a few weeks ago and loved it. Also really enjoyed Chefs de France and the ribs at Yak and Yeti were delicious. Also may want to try the drink there Yak Attack.