For some, yes. Some ppl cannot tolerate fatty foods at all. My surgeon said I probably had gallbladder disease for a REALLY REALLY long time (about 15 yrs) before it ever got bad enough for someone to check into it (I did not fit the *typical* gallbladder profile, so no one ever checked it.....besides, my pain was never intense for 14 yrs, 11 months and 3 weeks....so it never raised a red flag) ANYWAY.....I digress.....my surgeon said b/c I probably had it for so long, my body had learned to, in essence, function without it.
Now, if I eat a really really fatty meal, I can have abdominal cramping and....well, what follows abdominal cramping. But it's rare. And then there are times I can have a really really fatty meal and just be perfectly fine.