There are all very similar as far as rooms, amenities, transportation, so it all depends on what kind of themeing your family likes. Caribbean Beach (name speaks for itself); Coronado Springs (Southwest/Mexico); Port Orleans Riverside (old south). My favorite is Coronado Springs and I think the consensus would be that CSR has the best pool. If you plan on spending much time at Downtown Disney, PO is nice since there's a boat to DTD.