I was told I had a tumor in my head a few years ago, and was scheduled for a risky surgery to remove it. (This is where one of my tags came from.) This caused my to think about this very question. When it came down to it, I told one of my friends to just hook my MP3 player up to the sound system and put it on shuffle. I didn't want to talk to my family about it or think to much about it because that seemed too fatalistic!
BTW, the "thing" is still in my head. It's not doing anything, and they decided at the last minute that it was riskier to remove it than to leave it there.