We went Dec '05 with GF 63 who has Parkinsons. We chose Grand Floridan hotel because he was familiar with it from past visits and because of the monorail. He was most interested in Epcot so we did that on the first day while his energy was highest. By the time we got back to the countries, GF would sit outside and enjoy the entertainment while DD5 worked on her mask, met with characters, etc.
Throughout the week, we would to wrap up major events before dinnertime, giving GF/GM the opportunity to head back to the hotel if they wanted. We also made ADRs for Cinderella dinner at 1900 Park Fare one night because it was at our hotel.
Parades were another easy thing for us to do. We would find a spot and GF (my dad) would hold the spot with me while rest of family played before the parade started. Gave us some great one-on-one quality time and GF got to rest.
I was so impressed with how much GF enjoyed our visit. Epcot was by far his favorite place, with the parade/Lion King Festival at AK being right up there too.
Hope some of this helps.