We use the big ziploc bags to pack and it does make everything much easier. I will put all of my underwear, sox and nightgowns in one and squeeze out the air. Since I wear mostly sundresses, I just roll those up and each one of the big bags will hold 3-4 sundresses. My spouse does the same thing. Well, not the sundresses (smile), but he puts his underwear, sox and bathing suit into one ziploc and rolls his t-shirts and shorts to put in another. The only clothing we don't put in ziploc bags are things like jackets, sweaters, sweatshirts and jeans.
Nothing gets all that wrinkled, and since I don't like to iron (smile), I have found that taking 20 or so minutes to wet a washcloth, dump the wet washcloth and the wrinkled clothes into a dryer and then take them out in about 10 minutes will eliminate most of the wrinkles. We usually do this right after check-in, since when our kids were little they wanted to check out the pool right away and we got into the habit of doing that first thing. I just bring the hangers and empty collapsible laundry basket with me and it is so nice to start the vacation out without ironing(smile).