I got mine in with hardly any trouble (once you have it on your finger, put a drop of rewetting drops on it, the liquid will help it suction to your eye; for a while I was having trouble getting it to "stick" to my eye because my finger was still wet from the solution), but getting it back out was a whole 'nother ball of wax. I panicked and actually ended up sleeping in them the first night until I could get back to the eye doctor the next day, and of course it popped right out. Now I only have problems if my eyes are dry.
Rewetting drops will be your best friend until you get used to contacts. Always wash your hands with an unscented soap and dry them on a low lint towel if possible (getting a piece of lint in between your eyeball and contact *SUCKS*). Don't reuse your contact solution, and if you don't wear the lenses for an extended period of time, change the solution at least once a week. I also used one of those enzyme cleaners once a week.
Make sure you have a good pair of UVA/UVB blocking sunglasses. Your eyes will probably be sensitive until you get used to the lenses, so wear them whenever you're outside.
Take a minute to look at the lens on your finger. Then flip it over and see what it looks like that way. That's the easiest way to tell if your lenses are inside out or not. If they're right, they'll look like a cereal bowl (deep and round). If they aren't, they'll look like a fancy ashtray with a "lip" on them (shallow and flat on the edges).
Always do the same eye first. For me it was my left eye in first, because my left eye's vision is so much worse than my right. Then I would take out my right eye's lens first, followed by the left.
Never, ever, *EVER* use tap water to store/rinse your lenses, and never, ever, *EVER* use your spit (yeah, I know that sounds gross, but you'd be surprised what people do). Use only your solution, and make sure the tip doesn't touch anything when you use it. And follow the recommendation for if you can sleep in your lenses (once in a while if you get stuck somewhere without solution won't kill you, but if your lenses aren't rated for overnight wear, try not to do it), and for replacing them. I know some people stretch their lenses out past their toss date because they're expensive, but I don't think my eyesight is worth the risk.