Have only flown through MCO myself, but I have heard good things about Sanford. Here is the website for Sanford Airport where you can get some information on it. http://www.orlandosanfordairport.com/
We flew into Sanford last month. We had no problems getting around or finding our way out. We rented a car & they made sure we knew how to get where we were going & provided maps.
Sanford is super easy to navigate around. It is also convenient to SR417 which will bring you right into Disney. It is a toll road and costs about $6.00 form Sanford.
I4 is about 6 miles further down Lake Mary Blvd if you don't want to pay tolls.