We are in Central Indiana and looking for something to do over Fall Break. Basically, we get a long weekend (Thu-Sun). We aren't doing Disney this year since 1-we went in 2010 & 2011, 2-there aren't any discounts, 3-airfare is ridiculous, and 4-DD (HS sophomore) has some tough classes 1st trimester this year so we didn't want to take her out for extra days (which we do for Disney). We are thinking of doing a long weekend in Chicago.
Have fun planning your October trip....wherever you end up going!
Cleveland? Rock and Roll Hall of fame, http://meltbarandgrilled.com/, http://www.goodtimeiii.com/cms/
The University Circle area is full of great museums too I hear, but we didn't venture out of downtown. Cedar Point if it's open fall weekends and you are into roller coasters.

What about Sanibel/Captiva Fl. We have been going in Oct for over 20 years and the weather is beautiful and it isn't quite as crowded so you can get around fairly easily. Theres fishing, dolphin watching, a zoo in Naples around 30 minutes away called Jungle Larry's is great for kids. Its hands on exhibitions not just walk by cages and your close to Fort Myers with the pirate themes down on their beach.
) and drove from ABQ thru Arizona - visiting the Navajo National Monument, Monument Valley and traveling all along Route 66 - then onto the Grand Canyon and ended in Vegas! We had the BEST time! If you ask anyone in our family they will tell you it was the best trip we've ever taken! Every day was something new and amazing and fun. We all loved it! You can plan your own road trip adventure with a little googling and time. Our kids were 10, 8 and 5 at the time and since it was all so new for everyone even the time in the car (looking out at the scenery) was an experience. Sometimes the best trips as those where you find your own way...