If you like carrying a purse, consider a messenger bag. It drapes across one shoulder and fits secure to your body, but leaves your hands free and will not fall off. I have one that I love. It is large enough for all my necessities--wallet, mini first aid kit, bug bite stick, sunscreen, tissues, hand sanitizer, etc. I carry everything I need, but don't feel like a pack mule. Hubby carries a few necessities in the camera bag. I don't use the fanny packs because they hurt my lower back. The messenger bag does not. QVC sells some nice ones for travel -- I think the brand is Travelon. Mine came from Target about 5 years ago. It is great for displaying your pins also, like a previous poster said.
I'm envious of the people who can take their room key and just go for the day. Sorry but I do need my Imodium, chap-stick, insurance cards, cell phone, Advil and a bunch of other stuff. I think I may have issues--I call it Girl Scout syndrome!