The Venetian is a great place to stay. Sign up for their newsletters to get deals, hotel credit for food, etc.
Best to stay at that central part of the strip since that seems to be where a lot of the action is. Hotels in that part of the strip are the Venetian, Treasure Island, Mirage, Bellagio, Bally's, Paris, Wynn, Caesars. I'm sure there are other hotels, but those are the familiar hotels that most have mentioned on this thread.
When we went last year, we stayed at the Signature at MGM (behind the MGM). It was fabulous accommodations but we felt rather far away from the action. You can take the Deuce bus, but it takes FOREVER to get you to the central strip, not because it's a long ways by bus but because of all the pedestrian and car traffic. Things move pretty slow. We walked it several times, but it was really hot (90 deg F), hard on the feet (pounding the pavement in the cement jungle), and really bothersome with the people passing out those leaflets. The monorail is fast but it cost us $9 pp

scared1

each way.
If you go to Travelzoo.com, there are sometimes discounted tickets to see Vegas shows.
Vegas is a lot of fun!

Great eats, super entertainment, and fun gambling (esp if you happen to win some $$$

). Have a fabulous time!!!