We've stayed in VRBO homes in many locations , all with good results. In Kissimmee about 10 years ago, we got a 4BR, 3 bath big,newer ranch home with a pool and nice grounds overlooking a lake for about 100/night. Quiet community, about 20 minute drive from Disney. I liked it, but my young son said he'd rather stay in the Park next time. lol. Next time we stayed in a room at Port Orleans French Quarter, we loved the grounds and convenience, but that room got cramped quick. Another time we stayed at Nickolodean Studions, lol, son liked it, my wife and I did not.
Now we have a 2 BR deluxe condo at Wyndam Bonnett Creek lined up , about 180/night on Disney property (we found on VRBO), 5 minutes from Epcot, with fancy pools , and I'm hoping this will be the best of all.
So, feel confident in VRBO, but there are pros and cons with every place, like location/size/price/ambience/convenience and other features for you to weigh what will work best for you and your family or group. Good luck !