If it were me, I wouldn't go Ford, VW, Chevy, Chrysler, Pontiac, etc. Decent for the time-being, yes, but unless it's an expensive sports car or truck, these companies are not known for quality over time.
I would suggest a Honda or Toyota, which are both companies with products that last over time. My mom's best friend has a 1996 Honda Accord. I have a 1999 Honda CR-V. Neither one of us has encountered one single problem in all these years outside of routine things (oil changes, new tires, etc.).
As for fuel efficient and roomy, well, both don't necessarily go hand in hand. It's hard to get something that is extremely roomy that isn't an SUV or minivan.
My recommendations would be as follows though:
Toyota Prius (a hybrid car)
Toyota Camry (they have a hybrid version now as well)
Honda Civic (which also has a hybrid version)
Honda Pilot (an SUV that can seat up to 8 yes, but not as huge as you'd think; my mom bought one recently and LOVES it)
Honda CR-V (the new ones are slightly redesigned, but I LOVE my 1999 version and it is much better on gas than an average SUV. It also has the added plus of all-wheel drive).