I never get sick on ANYTHING, and got totally socked by Mission:Space. First off, I felt like I couldn't breathe during take-off. Then I was just funky-vertigo-y, like I was going to pass out. They have benches for people who get sick to lie down on. I was so embarrassed, but I had to lie there. After about 20 minutes I got up, but was still kind of shaky. An hour or two, I was fine. (And I followed all the rules.)
I think it is really smart of you to find out what it is about before riding. I didn't know how it worked until I was lying on the bench and the staff people explained how the ride worked and that people get better fast. But, you know, I still would have ridden it, because I never had problems, so...
Got dragged back on about 6 months later, and did fine.
I think it is a really GREAT ride if you don't get sick, which most people don't.