You've gotten good advice already - just wanted to second recs for:
Corky's or Central BBQ
Stax
Sun Studio
Graceland (you kind of have to go)
other favorite, fun restaurants are:
Gus' Fried Chicken
Soul Fish Cafe (in Cooper Young, a cute area)
Huey's (local burger chain)
I recommend the Holiday Inn, University of Memphis for a non-downtown location if you want something less expensive. It's part of the hospitality program and I've only had good luck there. I absolutely wouldn't stay as far away as Germantown or Southaven or outside of (or near) 240.
Google map it and you'll see.
Enjoy the trip. Memphis is a fantastic city.
The Residence Inn on Poplar Pike is between Germantown and Collierville, so farther away than Germantown. Walnut Grove @ Humphreys is going to put her right in the middle of that awful construction going on, on I240, ditto Primacy Parkway. I am not trying to be a downer, but those three caught my eye.
ETA: Isn't there a new hotel just off 385 at Hacks CrossRoad? I don't remember the name of it, though.
Edit again. The Marriott at Thousand Oaks has closed, and it was in a terrible part of town. Right at I-240 and Perkins, where we had already said don't stay near there.
Oops...right about the one on Poplar Pike....too far out. Also right about the Marriott on Thousand Oaks. I included the Humphreys and Primacy Parkway because their access to 240 is irrelevant to me...I am avoiding 240 at all costs right now. Easier and less stressful to just use city streets!
Huey's is yummy!
Fairfield inn east/Galaria?
I will also recommend the Rock and Soul Museum.
And I don't think I've seen anyone recommend visiting the Loraine Motel and also the Civil Rights Museum. Add that to your list.
Ok, VERY reasonable rates at the Hampton inn poplar. Would this be good? And the comfort inn downtown is also reasonable. Which one guys???
Yup, have been looking on trip advisor & they all get good reviews. Advantage to the comfort inn, being able to get around to many things without the car (safe to be out in that area at night, like coming home from a club?). But is it "old"? If we stay further out, we always have to drive & park.
You have been an angel and so helpful. I think I will book the comfort inn. Price difference is not much & this trip is really all about DH & his love of blues. (He's been tolerating my love of Disney for years so his turn!)