Personally, the part I hate about vacations is the un-packing upon returning home. For me, I pack 4 days worth of clothes, do a load mid-week and another one the night before we leave. That way, I only have a small amount to unpack and they go right into the dressers.
After taking a 7 Disney trips in the last 5 years, I realized that cool, lightweight clothing is all that's needed. I've learned to pack light and not waste my time packing/unpacking unnecessary clothing.
To me, washing the clothes is a "chore" no matter what, my personal preference is to do it in small loads. Since the washers/dryers are placed near the pools, I just schedule the laundry around our "pool time"
Helene