there is one area i can think of that feels very high. after victorville you hit the mountain pass and if you are in the more left lanes it is easy to notice how high you are if you look towards the left. so if you stay in the more right lanes through that part it is no big deal.
there are a few other places where you will notice a difference in elevation but it does not really feel like you are that high.
also it is not just one highway, you get off the 15 and go to the 60 then the 57 to ball road.
that is the way we go, and we go almost once a month. depending on if you stop and the length of it, it will take you 4 to 4.5 hrs